Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.

نویسندگان

  • M E Klepser
  • E J Wolfe
  • R N Jones
  • C H Nightingale
  • M A Pfaller
چکیده

Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 41 6  شماره 

صفحات  -

تاریخ انتشار 1997